Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects
نویسندگان
چکیده
منابع مشابه
Defects in Ribosomal Protein Genes Cause Cancer in Zebrafish
When James Watson and Francis Crick reported the structure of DNA in 1953, the mechanism of inheritance was instantly apparent. The complementary pairing of the DNA bases in the double helix, the pair famously wrote, “immediately suggests a possible copying mechanism for the genetic material.’’ The structure helped explain one of the central problems of modern biology: how does genetic material...
متن کاملRibosomal Protein Gene Knockdown Causes Developmental Defects in Zebrafish
The ribosomal proteins (RPs) form the majority of cellular proteins and are mandatory for cellular growth. RP genes have been linked, either directly or indirectly, to various diseases in humans. Mutations in RP genes are also associated with tissue-specific phenotypes, suggesting a possible role in organ development during early embryogenesis. However, it is not yet known how mutations in a pa...
متن کاملLoss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response
Ribosome is responsible for protein synthesis in all organisms and ribosomal proteins (RPs) play important roles in the formation of a functional ribosome. L11 was recently shown to regulate p53 activity through a direct binding with MDM2 and abrogating the MDM2-induced p53 degradation in response to ribosomal stress. However, the studies were performed in cell lines and the significance of thi...
متن کاملRecognition of ribosomal protein L11 by the protein trimethyltransferase PrmA.
Bacterial ribosomal protein L11 is post-translationally trimethylated at multiple residues by a single methyltransferase, PrmA. Here, we describe four structures of PrmA from the extreme thermophile Thermus thermophilus. Two apo-PrmA structures at 1.59 and 2.3 A resolution and a third with bound cofactor S-adenosyl-L-methionine at 1.75 A each exhibit distinct relative positions of the substrate...
متن کاملThermus thermophilus L11 methyltransferase, PrmA, is dispensable for growth and preferentially modifies free ribosomal protein L11 prior to ribosome assembly.
The ribosomal protein L11 in bacteria is posttranslationally trimethylated at multiple amino acid positions by the L11 methyltransferase PrmA, the product of the prmA gene. The role of L11 methylation in ribosome function or assembly has yet to be determined, although the deletion of Escherichia coli prmA has no apparent phenotype. We have constructed a mutant of the extreme thermophile Thermus...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2010
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2010.08396.x